Disordered proliferative endometrium is a somewhat vague term that generally indicates the unusual growth of endometrial cells. The term can refer to a form of simple endometrial hyperplasia — or the abnormal thickening of the endometrial lining — but it can indicate a more serious problem in some cases.
Is disordered proliferative endometrium normal?
Disordered proliferative endometrium is common in the perimenopausal years because of anovulatory cycles. In any case, the management of simple endometrial hyperplasia and disordered proliferative endometrium is usually identical, in the form of progestogenic compounds.
Does disordered proliferative endometrium mean cancer?
Sometimes a doctor may refer to the proliferation of your endometrial cells as disordered. This could mean a number of different things, depending on your individual diagnosis. For example, if your endometrial tissue in your uterus grows too fast, the cells can become malignant.
What is the treatment for disordered proliferative endometrium?
The most common treatment is progestin. This can be taken in several forms, including pill, shot, vaginal cream, or intrauterine device. Atypical types of endometrial hyperplasia, especially complex, increase your risk of getting cancer. If you have these types, you might consider a hysterectomy.
What causes proliferation of the endometrium?
Endometrial hyperplasia most often is caused by excess estrogen without progesterone. If ovulation does not occur, progesterone is not made, and the lining is not shed. The endometrium may continue to grow in response to estrogen. The cells that make up the lining may crowd together and may become abnormal.
Can endometrial biopsy wrong?
False-negative rates for office-based endometrial biopsy have been reported at more than 15% and d&c has up to an 11% false-negative rate for endometrial carcinoma. One study reported that endometrial biopsy had only a 43% sensitivity rate for detecting endometrial carcinoma.
How long before endometrial hyperplasia turns into cancer?
Atypical hyperplasia can turn into cancer of the womb. 20 years after diagnosis, around 28 out of every 100 women diagnosed with atypical hyperplasia will develop cancer of the womb. However, hysterectomy is a complete cure if carried out before the cancer develops.
What is the meaning of disordered proliferative endometrium?
Disordered proliferative endometrium is a somewhat vague term that generally indicates the unusual growth of endometrial cells. The term can refer to a form of simple endometrial hyperplasia — or the abnormal thickening of the endometrial lining — but it can indicate a more serious problem in some cases.
How do you know if you have atypical endometrial hyperplasia?
Symptoms of atypical endometrial hyperplasia include abnormal uterine bleeding, such as heavy menstrual bleeding, bleeding between menstrual periods, or postmenopausal bleeding.