The type of stability is generally divided into chemical, physical, microbiological, therapeutic, and toxicological. Drug stability can be categorized as pre-market and commercial (marketed product) stability.

What is drug stability?

Drug preparations are considered stable if the active ingredient can maintain its strength at the level specified on the label for the maximum anticipated shelf-life (the time period from the date of manufacture until administration to the animal) under environmental conditions likely to be encountered in actual use.

How many types of stability are there in pharma?

Two common types of stability tests are real-time and accelerated. Real-time tests are accomplished by storing pharmaceutical products according to the recommended conditions and checking or monitoring the product until it fails.

What are the different factors that affect drug stability?

Common factors that affect this stability include temperature, light, pH, oxidation and enzymatic degradation.

How does moisture affect drug stability?

It has long been known that moisture affects the stability of some drug substances. This presumes that the drug substance is not particularly hygroscopic, since, otherwise, the capsule shell will provide an unwanted source of moisture.

How does oxidation affect drug stability?

The main chemical reactions that affect the stability of a drug are oxidation and hydrolysis. Oxidation involves the removal of electrons from a molecule (or the addition of oxygen) and such reactions can be initiated by light, heat or certain trace metals.

How does a ship lose stability?

If a ship is grounded in a region where the water level is descending, at a certain draught it can lose stability. The angle of loll cannot be corrected by moving masses transversely; such an action can endanger the ship. Angles of loll should be corrected only by lowering the centre of gravity.

How do you control humidity?

How Can I Reduce My Humidity Levels?Use Your Air Conditioner. Actively Use Your Exhaust/Ventilation Fans. Take Cooler Showers. Fix Any Leaking Pipes. Keep Your Gutters Clean. Dry Your Laundry Outside. Get a Dehumidifier. Move Your House Plants.More items •30 May 2018

What is hygroscopic behavior?

Hygroscopicity is the tendency of a solid substance to absorb moisture from the surrounding atmosphere. A particular example of hygroscopic behavior is deliquescence which is exhibited by many water-soluble solids, including inorganic salts (e.g., calcium chloride).

How do you determine drug stability?

A products stability must be assessed with regard to its formulation; the influence of its pharmaceutical ingredients; the influence of the container and closure; the manufacturing and processing conditions; packaging components; storage conditions; anticipated conditions of shipping, temperature, light, and humidity;

Does spraying water increase humidity?

Fill a spray bottle and walk around your home, misting water into the air. The water sprayed into the air will evaporate quickly, thus increasing your home humidity levels.